A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability

The Mre11-Rad50-Nbs1 complex is a DNA doublestrand break sensor that mediates a tumor-suppressive DNA damage response (DDR) in cells undergoing oncogenic stress, yet the mechanisms underlying this effect are poorly understood. Using a genetically inducible primary mammary epithelial cell model, we d...

全面介紹

Na minha lista:
書目詳細資料
發表在:Cell Rep
Main Authors: Fagan-Solis, Katerina D., Simpson, Dennis A., Kumar, Rashmi J., Martelotto, Luciano G., Mose, Lisle E., Rashid, Naim U., Ho, Alice Y., Powell, Simon N., Wen, Y. Hannah, Parker, Joel S., Reis-Filho, Jorge S., Petrini, John H.J., Gupta, Gaorav P.
格式: Artigo
語言:Inglês
出版: 2020
主題:
Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7361372/
https://ncbi.nlm.nih.gov/pubmed/32023457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.01.020
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!

相似書籍