Convergent Evolution of HLA-C Downmodulation in HIV-1 and HIV-2

HLA-C-mediated antigen presentation induces the killing of human immunodeficiency virus (HIV)-infected CD4(+) T cells by cytotoxic T lymphocytes (CTLs). To evade killing, many HIV-1 group M strains decrease HLA-C surface levels using their accessory protein Vpu. However, some HIV-1 group M isolates...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Hopfensperger, Kristina, Richard, Jonathan, Stürzel, Christina M., Bibollet-Ruche, Frederic, Apps, Richard, Leoz, Marie, Plantier, Jean-Christophe, Hahn, Beatrice H., Finzi, Andrés, Kirchhoff, Frank, Sauter, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7360927/
https://ncbi.nlm.nih.gov/pubmed/32665270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00782-20
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