Expanding the Structural Diversity of Drimentines by Exploring the Promiscuity of Two N-methyltransferases

Methylation is envisioned as a promising way to rationally improve key pharmacokinetic characteristics of lead compounds. Although diverse tailoring enzymes are found to be clustered with cyclodipeptide synthases (CDPSs) to perform further modification reactions on the diketopiperazine (DKP) rings g...

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Bibliografski detalji
Izdano u:iScience
Glavni autori: Yao, Tingting, Liu, Jing, Jin, Enjing, Liu, Zengzhi, Li, Huayue, Che, Qian, Zhu, Tianjiao, Li, Dehai, Li, Wenli
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7358741/
https://ncbi.nlm.nih.gov/pubmed/32659721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101323
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