Expanding the Structural Diversity of Drimentines by Exploring the Promiscuity of Two N-methyltransferases

Methylation is envisioned as a promising way to rationally improve key pharmacokinetic characteristics of lead compounds. Although diverse tailoring enzymes are found to be clustered with cyclodipeptide synthases (CDPSs) to perform further modification reactions on the diketopiperazine (DKP) rings g...

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Detalhes bibliográficos
Publicado no:iScience
Main Authors: Yao, Tingting, Liu, Jing, Jin, Enjing, Liu, Zengzhi, Li, Huayue, Che, Qian, Zhu, Tianjiao, Li, Dehai, Li, Wenli
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7358741/
https://ncbi.nlm.nih.gov/pubmed/32659721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101323
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