Expanding the Structural Diversity of Drimentines by Exploring the Promiscuity of Two N-methyltransferases

Methylation is envisioned as a promising way to rationally improve key pharmacokinetic characteristics of lead compounds. Although diverse tailoring enzymes are found to be clustered with cyclodipeptide synthases (CDPSs) to perform further modification reactions on the diketopiperazine (DKP) rings g...

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Bibliographic Details
Published in:iScience
Main Authors: Yao, Tingting, Liu, Jing, Jin, Enjing, Liu, Zengzhi, Li, Huayue, Che, Qian, Zhu, Tianjiao, Li, Dehai, Li, Wenli
Format: Artigo
Language:Inglês
Published: Elsevier 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7358741/
https://ncbi.nlm.nih.gov/pubmed/32659721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101323
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