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Expanding the Structural Diversity of Drimentines by Exploring the Promiscuity of Two N-methyltransferases
Methylation is envisioned as a promising way to rationally improve key pharmacokinetic characteristics of lead compounds. Although diverse tailoring enzymes are found to be clustered with cyclodipeptide synthases (CDPSs) to perform further modification reactions on the diketopiperazine (DKP) rings g...
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| 發表在: | iScience |
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| Main Authors: | , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Elsevier
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7358741/ https://ncbi.nlm.nih.gov/pubmed/32659721 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101323 |
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