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Expanding the Structural Diversity of Drimentines by Exploring the Promiscuity of Two N-methyltransferases

Methylation is envisioned as a promising way to rationally improve key pharmacokinetic characteristics of lead compounds. Although diverse tailoring enzymes are found to be clustered with cyclodipeptide synthases (CDPSs) to perform further modification reactions on the diketopiperazine (DKP) rings g...

詳細記述

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書誌詳細
出版年:iScience
主要な著者: Yao, Tingting, Liu, Jing, Jin, Enjing, Liu, Zengzhi, Li, Huayue, Che, Qian, Zhu, Tianjiao, Li, Dehai, Li, Wenli
フォーマット: Artigo
言語:Inglês
出版事項: Elsevier 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7358741/
https://ncbi.nlm.nih.gov/pubmed/32659721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101323
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