CD56 regulates human NK cell cytotoxicity through Pyk2

Human natural killer (NK) cells are defined as CD56(+)CD3(−). Despite its ubiquitous expression on human NK cells the role of CD56 (NCAM) in human NK cell cytotoxic function has not been defined. In non-immune cells, NCAM can induce signaling, mediate adhesion, and promote exocytosis through interac...

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Udgivet i:eLife
Main Authors: Gunesch, Justin T, Dixon, Amera L, Ebrahim, Tasneem AM, Berrien-Elliott, Melissa M, Tatineni, Swetha, Kumar, Tejas, Hegewisch-Solloa, Everardo, Fehniger, Todd A, Mace, Emily M
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2020
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7358009/
https://ncbi.nlm.nih.gov/pubmed/32510326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.57346
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