Large DNA Methylation Nadirs Anchor Chromatin Loops Maintaining Hematopoietic Stem Cell Identity

Higher-order chromatin structure and DNA methylation are implicated in multiple developmental processes, but their relationship to cell state is unknown. Here, we find that large (>7.3kb) DNA methylation nadirs (termed “grand canyons”) can form long loops connecting anchor loci that may be dozens...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Zhang, Xiaotian, Jeong, Mira, Huang, Xingfan, Wang, Xue Qing, Wang, Xinyu, Zhou, Wanding, Shamim, Muhammad S., Gore, Haley, Himadewei, Pamela, Liu, Yushuai, Bochkov, Ivan D., Reyes, Jaime, Doty, Madison, Huang, Yung-Hsin, Jung, Haiyoung, Heikamp, Emily, Aiden, Aviva Presser, Li, Wei, Su, Jianzhong, Aiden, Erez Lieberman, Goodell, Margaret A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7357281/
https://ncbi.nlm.nih.gov/pubmed/32386543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.04.018
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