1-(1-Arylethylpiperidin-4-yl)thymine Analogs as Antimycobacterial TMPK Inhibitors

A series of Mycobacterium tuberculosis TMPK (MtbTMPK) inhibitors based on a reported compound 3 were synthesized and evaluated for their capacity to inhibit MtbTMPK catalytic activity and the growth of a virulent M. tuberculosis strain (H37Rv). Modifications of the scaffold of 3 failed to afford sub...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Jian, Yanlin, Hulpia, Fabian, D. P. Risseeuw, Martijn, Forbes, He Eun, Caljon, Guy, Munier-Lehmann, Hélène, I. M. Boshoff, Helena, Van Calenbergh, Serge
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7356956/
https://ncbi.nlm.nih.gov/pubmed/32560578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25122805
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