1-(1-Arylethylpiperidin-4-yl)thymine Analogs as Antimycobacterial TMPK Inhibitors

A series of Mycobacterium tuberculosis TMPK (MtbTMPK) inhibitors based on a reported compound 3 were synthesized and evaluated for their capacity to inhibit MtbTMPK catalytic activity and the growth of a virulent M. tuberculosis strain (H37Rv). Modifications of the scaffold of 3 failed to afford sub...

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Bibliografiske detaljer
Udgivet i:	Molecules
Main Authors:	Jian, Yanlin, Hulpia, Fabian, D. P. Risseeuw, Martijn, Forbes, He Eun, Caljon, Guy, Munier-Lehmann, Hélène, I. M. Boshoff, Helena, Van Calenbergh, Serge
Format:	Artigo
Sprog:	Inglês
Udgivet:	MDPI 2020
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7356956/ https://ncbi.nlm.nih.gov/pubmed/32560578 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25122805
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1-(1-Arylethylpiperidin-4-yl)thymine Analogs as Antimycobacterial TMPK Inhibitors

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