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Trimethoprim Action and Its Analogy with Thymine Starvation

In a minimal medium, trimethoprim is merely bacteriostatic on the prototroph Escherichia coli 114. The drug was bactericidal when the amino acids methionine and glycine, plus a purine or purine nucleoside, were also present. This response could be reversed completely when thymine and lysine were add...

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Detalhes bibliográficos
Main Authors: Amyes, S. G. B., Smith, J. T.
Formato: Artigo
Idioma:Inglês
Publicado em: 1974
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC428939/
https://ncbi.nlm.nih.gov/pubmed/4275615
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