Vorinostat Inhibits Brain Metastatic Colonization in a Model of Triple-Negative Breast Cancer and Induces DNA Double-Strand Breaks

PURPOSE: As chemotherapy and molecular therapy improve the systemic survival of breast cancer patients, the incidence of brain metastases increases. Few therapeutic strategies exist for the treatment of brain metastases because the blood-brain barrier severely limits drug access. We report the pharm...

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Udgivet i:Clin Cancer Res
Main Authors: Palmieri, Diane, Lockman, Paul R., Thomas, Fancy C., Hua, Emily, Herring, Jeanne, Hargrave, Elizabeth, Johnson, Matthew, Flores, Natasha, Qian, Yongzhen, Vega-Valle, Eleazar, Taskar, Kunal S., Rudraraju, Vinay, Mittapalli, Rajendar K., Gaasch, Julie A., Bohn, Kaci A., Thorsheim, Helen R., Liewehr, David J., Davis, Sean, Reilly, John F., Walker, Robert, Bronder, Julie L., Feigenbaum, Lionel, Steinberg, Seth M., Camphausen, Kevin, Meltzer, Paul S., Richon, Victoria M., Smith, Quentin R., Steeg, Patricia S.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7356672/
https://ncbi.nlm.nih.gov/pubmed/19789319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-1039
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