Application of the Gastrointestinal Simulator (GIS) Coupled with In Silico Modeling to Measure the Impact of Coca-Cola(®) on the Luminal and Systemic Behavior of Loratadine (BCS Class 2b)

In the present work, we explored if Coca-Cola(®) had a beneficial impact on the systemic outcome of the weakly basic drug loratadine (Wal-itin(®), immediate-release formulation, 10 mg, generic drug product). To map the contribution of underlying physiological variables that may positively impact the...

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Veröffentlicht in:Pharmaceutics
Hauptverfasser: Hens, Bart, Bermejo, Marival, Cristofoletti, Rodrigo, Amidon, Gregory E., Amidon, Gordon L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7355706/
https://ncbi.nlm.nih.gov/pubmed/32570975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12060566
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