Exploring Bioequivalence of Dexketoprofen Trometamol Drug Products with the Gastrointestinal Simulator (GIS) and Precipitation Pathways Analyses

The present work aimed to explain the differences in oral performance in fasted humans who were categorized into groups based on the three different drug product formulations of dexketoprofen trometamol (DKT) salt—Using a combination of in vitro techniques and pharmacokinetic analysis. The non-bioeq...

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Udgivet i:Pharmaceutics
Main Authors: Bermejo, Marival, Kuminek, Gislaine, Al-Gousous, Jozef, Ruiz-Picazo, Alejandro, Tsume, Yasuhiro, Garcia-Arieta, Alfredo, González-Alvarez, Isabel, Hens, Bart, Mudie, Deanna, Amidon, Gregory E., Rodriguez-Hornedo, Nair, Amidon, Gordon L.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6471271/
https://ncbi.nlm.nih.gov/pubmed/30884755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics11030122
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