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An In Vivo Predictive Dissolution Methodology (iPD Methodology) with a BCS Class IIb Drug Can Predict the In Vivo Bioequivalence Results: Etoricoxib Products

The purpose of this study was to predict in vivo performance of three oral products of Etoricoxib (Arcoxia(®) as reference and two generic formulations in development) by conducting in vivo predictive dissolution with GIS (Gastro Intestinal Simulator) and computational analysis. Those predictions we...

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Detalhes bibliográficos
Publicado no:Pharmaceutics
Main Authors: Gonzalez-Alvarez, Isabel, Bermejo, Marival, Tsume, Yasuhiro, Ruiz-Picazo, Alejandro, Gonzalez-Alvarez, Marta, Hens, Bart, Garcia-Arieta, Alfredo, Amidon, Greg E., Amidon, Gordon L.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8067797/
https://ncbi.nlm.nih.gov/pubmed/33917118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics13040507
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