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Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates

Buprenorphine plays a crucial role in the therapeutic management of pain in adults, adolescents and pediatric subpopulations. However, only few pharmacokinetic studies of buprenorphine in children, particularly neonates, are available as conducting clinical trials in this population is especially ch...

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Bibliografski detalji
Izdano u:Pharmaceutics
Glavni autori: Kovar, Lukas, Schräpel, Christina, Selzer, Dominik, Kohl, Yvonne, Bals, Robert, Schwab, Matthias, Lehr, Thorsten
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7355427/
https://ncbi.nlm.nih.gov/pubmed/32585880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12060578
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