Subunit composition of the mammalian serine-palmitoyltransferase defines the spectrum of straight and methyl-branched long-chain bases

Sphingolipids (SLs) are chemically diverse lipids that have important structural and signaling functions within mammalian cells. SLs are commonly defined by the presence of a long-chain base (LCB) that is normally formed by the conjugation of l-serine and palmitoyl-CoA. This pyridoxal 5-phosphate (P...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Lone, Museer A., Hülsmeier, Andreas J., Saied, Essa M., Karsai, Gergely, Arenz, Christoph, von Eckardstein, Arnold, Hornemann, Thorsten
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7355037/
https://ncbi.nlm.nih.gov/pubmed/32576697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2002391117
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