Cell Polarity Factor Par3 Binds SPTLC1 and Modulates Monocyte Serine Palmitoyltransferase Activity and Chemotaxis

Elevated sphingolipids have been associated with increased cardiovascular disease. Conversely, atherosclerosis is reduced in mice by blocking de novo synthesis of sphingolipids catalyzed by serine palmitoyltransferase (SPT). The SPT enzyme is composed of the SPTLC1 and -2 subunits, and here we descr...

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Hlavní autoři: Tamehiro, Norimasa, Mujawar, Zahedi, Zhou, Suiping, Zhuang, Debbie Z., Hornemann, Thorsten, von Eckardstein, Arnold, Fitzgerald, Michael L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757191/
https://ncbi.nlm.nih.gov/pubmed/19592499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.014365
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