FADS3 is a Δ14Z sphingoid base desaturase that contributes to gender differences in the human plasma sphingolipidome

Sphingolipids (SLs) are structurally diverse lipids that are defined by the presence of a long-chain base (LCB) backbone. Typically, LCBs contain a single Δ4E double bond (DB) (mostly d18:1), whereas the dienic LCB sphingadienine (d18:2) contains a second DB at the Δ14Z position. The enzyme introduc...

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Vydáno v:J Biol Chem
Hlavní autoři: Karsai, Gergely, Lone, Museer, Kutalik, Zoltán, Brenna, J. Thomas, Li, Hongde, Pan, Duojia, von Eckardstein, Arnold, Hornemann, Thorsten
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
Témata:
Accelerated Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7029104/
https://ncbi.nlm.nih.gov/pubmed/31862735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.AC119.011883
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