Generation and validation of small ADAMTS13 fragments for epitope mapping of anti‐ADAMTS13 autoantibodies in immune‐mediated thrombotic thrombocytopenic purpura

BACKGROUND: In immune‐mediated thrombotic thrombocytopenic purpura (iTTP), patients develop an immune response against the multidomain enzyme ADAMTS13. ADAMTS13 consists of a metalloprotease (M) and disintegrin‐like (D) domain, 8 thrombospondin type 1 repeats (T1‐T8), a cysteine‐rich (C), a spacer (...

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Dettagli Bibliografici
Pubblicato in:Res Pract Thromb Haemost
Autori principali: Kangro, Kadri, Roose, Elien, Schelpe, An‐Sofie, Tellier, Edwige, Kaplanski, Gilles, Voorberg, Jan, De Meyer, Simon F., Männik, Andres, Vanhoorelbeke, Karen
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
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Original Articles: Thrombosis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7354404/
https://ncbi.nlm.nih.gov/pubmed/32685903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/rth2.12379
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