Only Hematopoietic Stem and Progenitor Cells from Cord Blood Are Susceptible to Malignant Transformation by MLL-AF4 Translocations

Mixed lineage leukemia (MLL) (KMT2A) rearrangements (KMT2Ar) play a crucial role in leukemogenesis. Dependent on age, major differences exist regarding disease frequency, main fusion partners and prognosis. In infants, up to 80% of acute lymphoid leukemia (ALL) bear a MLL translocation and half of t...

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Publicado en:Cancers (Basel)
Autores principales: Secker, Kathy-Ann, Bruns, Lukas, Keppeler, Hildegard, Jeong, Johan, Hentrich, Thomas, Schulze-Hentrich, Julia M., Mankel, Barbara, Fend, Falko, Schneidawind, Dominik, Schneidawind, Corina
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7352867/
https://ncbi.nlm.nih.gov/pubmed/32517300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12061487
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