MAT2A as Key Regulator and Therapeutic Target in MLLr Leukemogenesis

Epigenetic dysregulation plays a pivotal role in mixed-lineage leukemia (MLL) pathogenesis, therefore serving as a suitable therapeutic target. S-adenosylmethionine (SAM) is the universal methyl donor in human cells and is synthesized by methionine adenosyltransferase 2A (MAT2A), which is deregulate...

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Bibliografiska uppgifter
I publikationen:Cancers (Basel)
Huvudupphovsmän: Secker, Kathy-Ann, Bloechl, Bianca, Keppeler, Hildegard, Duerr-Stoerzer, Silke, Schmid, Hannes, Schneidawind, Dominik, Jeong, Johan, Hentrich, Thomas, Schulze-Hentrich, Julia M., Schneidawind, Corina
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7281730/
https://ncbi.nlm.nih.gov/pubmed/32456310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12051342
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