Only Hematopoietic Stem and Progenitor Cells from Cord Blood Are Susceptible to Malignant Transformation by MLL-AF4 Translocations

Mixed lineage leukemia (MLL) (KMT2A) rearrangements (KMT2Ar) play a crucial role in leukemogenesis. Dependent on age, major differences exist regarding disease frequency, main fusion partners and prognosis. In infants, up to 80% of acute lymphoid leukemia (ALL) bear a MLL translocation and half of t...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancers (Basel)
Prif Awduron: Secker, Kathy-Ann, Bruns, Lukas, Keppeler, Hildegard, Jeong, Johan, Hentrich, Thomas, Schulze-Hentrich, Julia M., Mankel, Barbara, Fend, Falko, Schneidawind, Dominik, Schneidawind, Corina
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7352867/
https://ncbi.nlm.nih.gov/pubmed/32517300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12061487
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg