Nifedipine Exacerbates Lipogenesis in the Kidney via KIM-1, CD36, and SREBP Upregulation: Implications from an Animal Model for Human Study

Dysregulation of fatty acid oxidation and accumulation of fatty acids can cause kidney injury. Nifedipine modulates lipogenesis-related transcriptional factor SREBP-1/2 in proximal tubular cells by inhibiting the Adenosine 5‘-monophosphate (AMP)-activated protein kinase (AMPK) pathway in vitro. Howe...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Lin, Yen-Chung, Wang, Jhih-Cheng, Wu, Mai-Szu, Lin, Yuh-Feng, Chen, Chang-Rong, Chen, Chang-Yu, Chen, Kuan-Chou, Peng, Chiung-Chi
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7352626/
https://ncbi.nlm.nih.gov/pubmed/32575412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21124359
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