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Nifedipine Upregulates ATF6-α, Caspases -12, -3, and -7 Implicating Lipotoxicity-Associated Renal ER Stress

Nifedipine (NF) is reported to have many beneficial effects in antihypertensive therapy. Recently, we found that NF induced lipid accumulation in renal tubular cells. Palmitic acid-induced renal lipotoxicity was found to be partially mediated by endoplasmic reticular (ER) stress, while it can also b...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Peng, Chiung-Chi, Chen, Chang-Rong, Chen, Chang-Yu, Lin, Yen-Chung, Chen, Kuan-Chou, Peng, Robert Y.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7246953/
https://ncbi.nlm.nih.gov/pubmed/32365658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21093147
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