Rationally Designed Antibodies as Research Tools to Study the Structure–Toxicity Relationship of Amyloid-β Oligomers

Alzheimer’s disease is associated with the aggregation of the amyloid-β peptide (Aβ), resulting in the deposition of amyloid plaques in brain tissue. Recent scrutiny of the mechanisms by which Aβ aggregates induce neuronal dysfunction has highlighted the importance of the Aβ oligomers of this protei...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Limbocker, Ryan, Mannini, Benedetta, Cataldi, Rodrigo, Chhangur, Shianne, Wright, Aidan K., Kreiser, Ryan P., Albright, J. Alex, Chia, Sean, Habchi, Johnny, Sormanni, Pietro, Kumita, Janet R., Ruggeri, Francesco S., Dobson, Christopher M., Chiti, Fabrizio, Aprile, Francesco A., Vendruscolo, Michele
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7352524/
https://ncbi.nlm.nih.gov/pubmed/32630615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21124542
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