Potential Positive and Negative Consequences of ZnT8 Inhibition

SLC30A8 encodes the zinc transporter ZnT8. SLC30A8 haploinsufficiency protects against type 2 diabetes (T2D), suggesting that ZnT8 inhibitors may prevent T2D. We show here that, while adult chow fed Slc30a8 haploinsufficient and knockout (KO) mice have normal glucose tolerance, they are protected ag...

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Publicat a:J Endocrinol
Autors principals: Syring, Kristen E., Bosma, Karin J., Goleva, Slavina B., Singh, Kritika, Oeser, James K., Lopez, Christopher A., Skaar, Eric P., McGuinness, Owen P., Davis, Lea K., Powell, David R., O’Brien, Richard M.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351606/
https://ncbi.nlm.nih.gov/pubmed/32485672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JOE-20-0138
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