Potential Positive and Negative Consequences of ZnT8 Inhibition

SLC30A8 encodes the zinc transporter ZnT8. SLC30A8 haploinsufficiency protects against type 2 diabetes (T2D), suggesting that ZnT8 inhibitors may prevent T2D. We show here that, while adult chow fed Slc30a8 haploinsufficient and knockout (KO) mice have normal glucose tolerance, they are protected ag...

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Pubblicato in:J Endocrinol
Autori principali: Syring, Kristen E., Bosma, Karin J., Goleva, Slavina B., Singh, Kritika, Oeser, James K., Lopez, Christopher A., Skaar, Eric P., McGuinness, Owen P., Davis, Lea K., Powell, David R., O’Brien, Richard M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351606/
https://ncbi.nlm.nih.gov/pubmed/32485672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JOE-20-0138
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