Evidence That Evolution of the Diabetes Susceptibility Gene SLC30A8 that Encodes the Zinc Transporter ZnT8 Drives Variations in Pancreatic Islet Zinc Content in Multiple Species

Pancreatic islet zinc levels vary widely between species. Very low islet zinc levels in Guinea pigs were thought to be driven by evolution of the INS gene that resulted in the generation of an isoform lacking a histidine at amino acid 10 in the B chain of insulin that is unable to bind zinc. However...

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Detalhes bibliográficos
Publicado no:J Mol Evol
Main Authors: Bosma, Karin J., Syring, Kristen E., Oeser, James K., Lee, Jason D., Benninger, Richard K. P., Pamenter, Matthew E., O’Brien, Richard M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6699160/
https://ncbi.nlm.nih.gov/pubmed/31273433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00239-019-09898-0
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