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TMIE defines pore and gating properties of the mechanotransduction channel of mammalian cochlear hair cells
TMC1 and TMC2 have been proposed to form the pore of the mechanotransduction channel of cochlear hair cells. Here we show that TMC1/2 cannot form mechanotransduction channels in cochlear hair cells without TMIE. TMIE binds to TMC1/2 and a TMIE mutation that perturbs TMC1/2 binding abolishes mechanot...
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| Pubblicato in: | Neuron |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7351599/ https://ncbi.nlm.nih.gov/pubmed/32343945 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2020.03.033 |
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