TMIE defines pore and gating properties of the mechanotransduction channel of mammalian cochlear hair cells

TMC1 and TMC2 have been proposed to form the pore of the mechanotransduction channel of cochlear hair cells. Here we show that TMC1/2 cannot form mechanotransduction channels in cochlear hair cells without TMIE. TMIE binds to TMC1/2 and a TMIE mutation that perturbs TMC1/2 binding abolishes mechanot...

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Vydáno v:Neuron
Hlavní autoři: Cunningham, Christopher L., Qiu, Xufeng, Wu, Zizhen, Zhao, Bo, Peng, Guihong, Kim, Ye-Hyun, Lauer, Amanda, Müller, Ulrich
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351599/
https://ncbi.nlm.nih.gov/pubmed/32343945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2020.03.033
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