CDK-Independent and PCNA-Dependent Functions of p21 in DNA Replication

p21(Waf/CIP1) is a small unstructured protein that binds and inactivates cyclin-dependent kinases (CDKs). To this end, p21 levels increase following the activation of the p53 tumor suppressor. CDK inhibition by p21 triggers cell-cycle arrest in the G1 and G2 phases of the cell cycle. In the absence...

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Bibliographic Details
Published in:Genes (Basel)
Main Authors: Mansilla, Sabrina Florencia, De La Vega, María Belén, Calzetta, Nicolás Luis, Siri, Sebastián Omar, Gottifredi, Vanesa
Format: Artigo
Language:Inglês
Published: MDPI 2020
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7349641/
https://ncbi.nlm.nih.gov/pubmed/32481484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes11060593
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