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CDK-Independent and PCNA-Dependent Functions of p21 in DNA Replication
p21(Waf/CIP1) is a small unstructured protein that binds and inactivates cyclin-dependent kinases (CDKs). To this end, p21 levels increase following the activation of the p53 tumor suppressor. CDK inhibition by p21 triggers cell-cycle arrest in the G1 and G2 phases of the cell cycle. In the absence...
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| Publicado no: | Genes (Basel) |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7349641/ https://ncbi.nlm.nih.gov/pubmed/32481484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes11060593 |
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