Reciprocal Interplay Between Astrocytes and CD4+ Cells Affects Blood-Brain Barrier and Neuronal Function in Response to β Amyloid

Background: In Alzheimer’s disease (AD) neuronal degeneration is associated with gliosis and infiltration of peripheral blood mononuclear cells (PBMCs), which participate in neuroinflammation. Defects at the blood-brain barrier (BBB) facilitate PBMCs migration towards the central nervous system (CNS...

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Publicat a:Front Mol Neurosci
Autors principals: Spampinato, Simona Federica, Merlo, Sara, Fagone, Evelina, Fruciano, Mary, Sano, Yasuteru, Kanda, Takashi, Sortino, Maria Angela
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Neuroscience
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7347984/
https://ncbi.nlm.nih.gov/pubmed/32719583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2020.00120
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