Reciprocal Interplay Between Astrocytes and CD4+ Cells Affects Blood-Brain Barrier and Neuronal Function in Response to β Amyloid

Background: In Alzheimer’s disease (AD) neuronal degeneration is associated with gliosis and infiltration of peripheral blood mononuclear cells (PBMCs), which participate in neuroinflammation. Defects at the blood-brain barrier (BBB) facilitate PBMCs migration towards the central nervous system (CNS...

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Main Authors: Simona Federica Spampinato, Sara Merlo, Evelina Fagone, Mary Fruciano, Yasuteru Sano, Takashi Kanda, Maria Angela Sortino
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-07-01
Colecção:Frontiers in Molecular Neuroscience
Assuntos:
BBB
Th2
IL-4
BDNF
synaptophysin
neurodegeneration
Acesso em linha:https://www.frontiersin.org/article/10.3389/fnmol.2020.00120/full
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