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Clustering of human prion protein and α-synuclein oligomers requires the prion protein N-terminus
The interaction of prion protein (PrP) and α-synuclein (αSyn) oligomers causes synaptic impairment that might trigger Parkinson’s disease and other synucleinopathies. Here, we report that αSyn oligomers (αSynO) cluster with human PrP (huPrP) into micron-sized condensates. Multivalency of αSyn within...
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| Publicado en: | Commun Biol |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7347944/ https://ncbi.nlm.nih.gov/pubmed/32647130 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-1085-z |
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