Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice

The spread of the SARS-CoV-2 into a global pandemic within a few months of onset motivates the development of a rapidly scalable vaccine. Here, we present a self-amplifying RNA encoding the SARS-CoV-2 spike protein encapsulated within a lipid nanoparticle (LNP) as a vaccine. We observe remarkably hi...

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Vydáno v:Nat Commun
Hlavní autoři: McKay, Paul F., Hu, Kai, Blakney, Anna K., Samnuan, Karnyart, Brown, Jonathan C., Penn, Rebecca, Zhou, Jie, Bouton, Clément R., Rogers, Paul, Polra, Krunal, Lin, Paulo J. C., Barbosa, Christopher, Tam, Ying K., Barclay, Wendy S., Shattock, Robin J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7347890/
https://ncbi.nlm.nih.gov/pubmed/32647131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17409-9
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