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Innate Inhibiting Proteins Enhance Expression and Immunogenicity of Self-Amplifying RNA

Self-amplifying RNA (saRNA) is a cutting-edge platform for both nucleic acid vaccines and therapeutics. saRNA is self-adjuvanting, as it activates types I and III interferon (IFN), which enhances the immunogenicity of RNA vaccines but can also lead to inhibition of translation. In this study, we scr...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Blakney, Anna K., McKay, Paul F., Bouton, Clément R., Hu, Kai, Samnuan, Karnyart, Shattock, Robin J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7935664/
https://ncbi.nlm.nih.gov/pubmed/33352107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.11.011
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