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The Skin You Are In: Design-of-Experiments Optimization of Lipid Nanoparticle Self-Amplifying RNA Formulations in Human Skin Explants

[Image: see text] Messenger RNA (mRNA) is a promising tool for biotherapeutics, and self-amplifying mRNA (saRNA) is particularly advantageous, because it results in abundant protein expression and production is easily scalable. While mRNA therapeutics have been shown to be highly effective in small...

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Detalhes bibliográficos
Publicado no:ACS Nano
Main Authors: Blakney, Anna K., McKay, Paul F., Ibarzo Yus, Bárbara, Hunter, Judith E., Dex, Elizabeth A., Shattock, Robin J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007275/
https://ncbi.nlm.nih.gov/pubmed/31046232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.9b01774
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