Big Is Beautiful: Enhanced saRNA Delivery and Immunogenicity by a Higher Molecular Weight, Bioreducible, Cationic Polymer

[Image: see text] Self-amplifying RNA (saRNA) vaccines are highly advantageous, as they result in enhanced protein expression compared to mRNA (mRNA), thus minimizing the required dose. However, previous delivery strategies were optimized for siRNA or mRNA and do not necessarily deliver saRNA effici...

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Dettagli Bibliografici
Pubblicato in:ACS Nano
Autori principali: Blakney, Anna K., Zhu, Yunqing, McKay, Paul F., Bouton, Clément R., Yeow, Jonathan, Tang, Jiaqing, Hu, Kai, Samnuan, Karnyart, Grigsby, Christopher L., Shattock, Robin J., Stevens, Molly M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2020
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7304921/
https://ncbi.nlm.nih.gov/pubmed/32267667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.0c00326
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