Big Is Beautiful: Enhanced saRNA Delivery and Immunogenicity by a Higher Molecular Weight, Bioreducible, Cationic Polymer

[Image: see text] Self-amplifying RNA (saRNA) vaccines are highly advantageous, as they result in enhanced protein expression compared to mRNA (mRNA), thus minimizing the required dose. However, previous delivery strategies were optimized for siRNA or mRNA and do not necessarily deliver saRNA effici...

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Detalhes bibliográficos
Publicado no:ACS Nano
Main Authors: Blakney, Anna K., Zhu, Yunqing, McKay, Paul F., Bouton, Clément R., Yeow, Jonathan, Tang, Jiaqing, Hu, Kai, Samnuan, Karnyart, Grigsby, Christopher L., Shattock, Robin J., Stevens, Molly M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7304921/
https://ncbi.nlm.nih.gov/pubmed/32267667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.0c00326
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