Factors influencing pharmacokinetics of warfarin in African–Americans: implications for pharmacogenetic dosing algorithms

AIM: This study attempted to identify predictors of S-warfarin clearance (CL[S]) and to make a pharmacokinetic evaluation of genotype-based dosing algorithms in African–Americans. METHODS: Using plasma S-warfarin concentration (Cp[S]) at a steady state and eight SNPs previously shown to influence wa...

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Bibliographic Details
Published in:Pharmacogenomics
Main Authors: Nagai, Rui, Ohara, Minami, Cavallari, Larisa H, Drozda, Katarzyna, Patel, Shitalben R, Nutescu, Edith A, Perera, Minoli A, Hernandez, Wenndy, Kaneko, Naoko, Hibiya, Manabu, Takahashi, Harumi
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7347085/
https://ncbi.nlm.nih.gov/pubmed/25712185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/pgs.14.160
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