Fe Porphyrin-Based SOD Mimic and Redox-Active Compound, (OH)FeTnHex-2-PyP(4+), in a Rodent Ischemic Stroke (MCAO) Model: Efficacy and Pharmacokinetics as Compared to Its Mn Analogue, (H(2)O)MnTnHex-2-PyP(5+)

Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, (H(2)O)MnTnHex-2-PyP(5+) (MnHex) carrying long hexyl chains, is a lipophilic mimic of superoxide dismutase (SOD) and a redox-active drug candidate. MnHex crosses the blood–brain barrier, and improved neurologic outcome and decreased infarct s...

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Veröffentlicht in:Antioxidants (Basel)
Hauptverfasser: Li, Litao, Tovmasyan, Artak, Sheng, Huaxin, Xu, Bin, Sampaio, Romulo S., Reboucas, Julio S., Warner, David S., Batinic-Haberle, Ines, Spasojevic, Ivan
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7346179/
https://ncbi.nlm.nih.gov/pubmed/32492872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox9060467
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