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Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP(5+) and MnTnHex-2-PyP(5+)

The cationic, ortho Mn(III) N-alkylpyridylporphyrins (alkyl=ethyl, E, and n-hexyl, nHex) MnTE-2-PyP(5+) (AEOL10113, FBC-007) and MnTnHex-2-PyP(5+) have proven efficacious in numerous in vivo animal models of diseases having oxidative stress in common. The remarkable therapeutic efficacy observed is...

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Main Authors:	Weitner, Tin, Kos, Ivan, Sheng, Huaxin, Tovmasyan, Artak, Reboucas, Julio S., Fan, Ping, Warner, David S., Vujaskovic, Zeljko, Batinic-Haberle, Ines, Spasojevic, Ivan
Format:	Artigo
Jezik:	Inglês
Izdano:	2013
Teme:	Article
Online dostop:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3763724/ https://ncbi.nlm.nih.gov/pubmed/23328731 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2013.01.006
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Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP(5+) and MnTnHex-2-PyP(5+)

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