Neuroprotective Efficacy from a Lipophilic Redox-Modulating Mn(III) N-Hexylpyridylporphyrin, MnTnHex-2-PyP: Rodent Models of Ischemic Stroke and Subarachnoid Hemorrhage

Intracerebroventricular treatment with redox-regulating Mn(III) N-hexylpyridylporphyrin (MnPorphyrin) is remarkably efficacious in experimental central nervous system (CNS) injury. Clinical development has been arrested because of poor blood-brain barrier penetration. Mn(III) meso-tetrakis (N-hexylp...

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Detalhes bibliográficos
Main Authors: Sheng, Huaxin, Spasojevic, Ivan, Tse, Hubert M., Jung, Jin Yong, Hong, Jun, Zhang, Zhiquan, Piganelli, Jon D., Batinic-Haberle, Ines, Warner, David S.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
Assuntos:
Drug Discovery and Translational Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164343/
https://ncbi.nlm.nih.gov/pubmed/21652782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.176701
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