Spp1 (osteopontin) promotes TGFβ processing in fibroblasts of dystrophin-deficient muscles through matrix metalloproteinases

Duchenne muscular dystrophy (DMD) is caused by mutations in the gene encoding dystrophin. Prior work has shown that DMD progression can vary, depending on the genetic makeup of the patient. Several modifier alleles have been identified including LTBP4 and SPP1. We previously showed that Spp1 exacerb...

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Dettagli Bibliografici
Pubblicato in:Hum Mol Genet
Autori principali: Kramerova, Irina, Kumagai-Cresse, Chino, Ermolova, Natalia, Mokhonova, Ekaterina, Marinov, Masha, Capote, Joana, Becerra, Diana, Quattrocelli, Mattia, Crosbie, Rachelle H, Welch, Ellen, McNally, Elizabeth M, Spencer, Melissa J
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
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General Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7345878/
https://ncbi.nlm.nih.gov/pubmed/31411676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz181
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