Single-cell RNA sequencing reveals that lung mesenchymal progenitor cells in IPF exhibit pathological features early in their differentiation trajectory

In Idiopathic Pulmonary Fibrosis (IPF), there is unrelenting scarring of the lung mediated by pathological mesenchymal progenitor cells (MPCs) that manifest autonomous fibrogenicity in xenograft models. To determine where along their differentiation trajectory IPF MPCs acquire fibrogenic properties,...

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Publicado no:Sci Rep
Main Authors: Beisang, Daniel J., Smith, Karen, Yang, Libang, Benyumov, Alexey, Gilbertsen, Adam, Herrera, Jeremy, Lock, Eric, Racila, Emilian, Forster, Colleen, Sandri, Brian J., Henke, Craig A., Bitterman, Peter B.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7341888/
https://ncbi.nlm.nih.gov/pubmed/32636398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-66630-5
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