Dicer1 Deficiency in the Idiopathic Pulmonary Fibrosis Fibroblastic Focus Promotes Fibrosis by Suppressing MicroRNA Biogenesis

Rationale: The lung extracellular matrix (ECM) in idiopathic pulmonary fibrosis (IPF) mediates progression of fibrosis by decreasing fibroblast expression of miR-29 (microRNA-29), a master negative regulator of ECM production. The molecular mechanism is undefined. IPF-ECM is stiffer than normal. Sti...

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Detaylı Bibliyografya
Yayımlandı:Am J Respir Crit Care Med
Asıl Yazarlar: Herrera, Jeremy, Beisang, Daniel J., Peterson, Mark, Forster, Colleen, Gilbertsen, Adam, Benyumov, Alexey, Smith, Karen, Korenczuk, Christopher E., Barocas, Victor H., Guenther, Kacey, Hite, Ryan, Zhang, Lin, Henke, Craig A., Bitterman, Peter B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Thoracic Society 2018
Konular:
Original Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6118029/
https://ncbi.nlm.nih.gov/pubmed/29579397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201709-1823OC
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