Dicer1 Deficiency in the Idiopathic Pulmonary Fibrosis Fibroblastic Focus Promotes Fibrosis by Suppressing MicroRNA Biogenesis

Rationale: The lung extracellular matrix (ECM) in idiopathic pulmonary fibrosis (IPF) mediates progression of fibrosis by decreasing fibroblast expression of miR-29 (microRNA-29), a master negative regulator of ECM production. The molecular mechanism is undefined. IPF-ECM is stiffer than normal. Sti...

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Detalhes bibliográficos
Publicado no:Am J Respir Crit Care Med
Main Authors: Herrera, Jeremy, Beisang, Daniel J., Peterson, Mark, Forster, Colleen, Gilbertsen, Adam, Benyumov, Alexey, Smith, Karen, Korenczuk, Christopher E., Barocas, Victor H., Guenther, Kacey, Hite, Ryan, Zhang, Lin, Henke, Craig A., Bitterman, Peter B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6118029/
https://ncbi.nlm.nih.gov/pubmed/29579397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201709-1823OC
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