Single-cell RNA sequencing reveals that lung mesenchymal progenitor cells in IPF exhibit pathological features early in their differentiation trajectory

In Idiopathic Pulmonary Fibrosis (IPF), there is unrelenting scarring of the lung mediated by pathological mesenchymal progenitor cells (MPCs) that manifest autonomous fibrogenicity in xenograft models. To determine where along their differentiation trajectory IPF MPCs acquire fibrogenic properties,...

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Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Beisang, Daniel J., Smith, Karen, Yang, Libang, Benyumov, Alexey, Gilbertsen, Adam, Herrera, Jeremy, Lock, Eric, Racila, Emilian, Forster, Colleen, Sandri, Brian J., Henke, Craig A., Bitterman, Peter B.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7341888/
https://ncbi.nlm.nih.gov/pubmed/32636398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-66630-5
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