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Tubulosine selectively inhibits JAK3 signalling by binding to the ATP‐binding site of the kinase of JAK3
Gain‐ or loss‐of‐function mutations in Janus kinase 3 (JAK3) contribute to the pathogenesis of various haematopoietic malignancies and immune disorders, suggesting that aberrant JAK3 signalling is an attractive therapeutic target to treat these disorders. In this study, we performed structure‐based...
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| Publicado no: | J Cell Mol Med |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7339168/ https://ncbi.nlm.nih.gov/pubmed/32558259 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.15362 |
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