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Phosphine-Catalyzed α-Umpolung–Aldol Reaction for the Synthesis of Benzo[b]azapin-3-ones

A novel phosphine-catalyzed intermolecular cyclization between 2-sulfonamidobenzaldehyes and ynones is reported. This methodology serves as a conduit for the construction of benzo[b]azepin-3-ones in good to excellent yields under mild conditions. The resulting 2-benzylidene moieties are formed exclu...

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Detalhes bibliográficos
Publicado no:Org Lett
Main Authors: Zhang, Kui, Cai, Lingchao, Hong, Sooji, Kwon, Ohyun
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7338222/
https://ncbi.nlm.nih.gov/pubmed/31247774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.9b01749
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